Zinedine Zidane finally has all his men recovered from injuries, as Karim Benzema is back to full training and he could make his return in this match, although he is not expected to feature from the start.
The Los Merengues manager will only miss Pepe and Sergio Ramos through suspension. Thus, Raphael Varane and Nacho Fernandez will be the centre-back pair.
Marcelo will feature at left-back and Danilo could come in at right-back to give Daniel Carvajal some rest.
In midfield, Casemiro seems to have become a guaranteed starter and he is expected to feature alongside Luka Modric and Toni Kroos.
The main doubt is whether Zidane will choose Isco, James Rodriguez or Lucas Vazquez to accompany Gareth Bale and Cristiano Ronaldo in the forward line.
Meanwhile, Unai Emery has plenty of losses to visit Los Blancos. Konoplyanka, N’Zonzi and Vitolo will miss the game through injury, and Ever Banega is suspended.
Sevilla need a victory to get closer to the fourth position in the table that would qualify them for the Champions League.
Possible line-ups:
Real Madrid: Navas; Danilo, Varane, Nacho Fernandez, Marcelo; Modric, Casemiro, Kroos; Vazquez, Ronaldo, Bale.
Sevilla: Rico; Coke, Rami, Carrico, Tremoulinas; Cristoforo, Krychowiak; Reyes, Iborra, Krohn-Dehli; Gameiro.
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